By Elizabeth A. Montgomery MD, Lysandra Voltaggio MD
Gastrointestinal mucosal biopsies are an energetic a part of the pathologist’s day and feature elevated some time past few years as endoscopic screening has turn into extra general. This new full-color moment version of Biopsy Interpretation of the Gastrointestinal Tract Mucosa has been elevated into concise, finished volumes to supply extra whole insurance of either non-neoplastic and neoplastic entities. just like the different books within the Biopsy Interpretation Series, those volumes are useful references for pathologists to exploit whilst making diagnostic judgements in keeping with biopsy specimens.
Volume 2 of this moment variation makes a speciality of interpretation of neoplastic gastrointestinal mucosal biopsies. assurance is geared to day-by-day perform and comprises mucosal biopsies from the esophagus, abdominal, small gut, huge gut, and anus. A significant other site will contain the entire three hundred print illustrations plus an extra 750 e-figures.
Volume 1 specializes in non-neoplastic biopsies and released in November 2011.
Read or Download Biopsy Interpretation of the Gastrointestinal Tract Mucosa: Volume 2: Neoplastic PDF
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Additional resources for Biopsy Interpretation of the Gastrointestinal Tract Mucosa: Volume 2: Neoplastic
In the past, esophagectomy was typically offered as a treatment in patients with high-grade dysplasia. Nevertheless, using modern techniques, endoscopic treatment has become the standard (5,16). Surveillance epidemiology and end results (SEER) data show that patients with high-grade dysplasia and early carcinomas have the same mortality whether managed endoscopically or surgically (39). More current practice is to sample aggressively for occult invasive carcinoma and perform close follow-up or endoscopic intervention.
34). On cytologic evaluation, lesions could have hyperchromasia, nuclear membrane irregularities, and increased mitoses in the deeper aspects, and these matured to the surface. Loss of nuclear polarity was not a feature of IND. In the presence of inflammation, more striking architectural abnormalities were to be included in the indefinite category. This interpretation can also be applied when tangential embedding does not allow assessment between the glands and the surface. Some cases display peculiar hypermucinous features, and it is unclear whether they are neoplastic or reparative (e-Figs.
Neuroendocrine carcinomas (Grade 3) are high-grade lesions and can be classified as “small cell” or “large cell” types (92). Both types are characterized by aggressive behavior. Most such tumors are encountered in men (although they are rare) and some examples of large cell neuroendocrine carcinomas are reported in association with Barrett mucosa. Those defined as “large cell neuroendocrine carcinomas” (Fig. 53, e-Figs. 210) display an organoid pattern with solid nests or acinar structures whereas those termed “small cell carcinomas” tend to form solid sheets and nests and are composed cells with small dark nuclei and minimal cytoplasm or larger cells with more cytoplasm (Fig.