By Institute of Medicine
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Additional resources for Addressing the Threat of Drug-Resistant Tuberculosis: A Realistic Assessment of the Challenge: Workshop Summary
However, even new drugs must be used only in combination, XDR TB is MDR TB that is also resistant to any one of the fluoroquinolones and any one of the second-line injectable drugs. 4 percent. The Global Laboratory Initiative was launched to promote the detection of TB and drugresistant TB. 17 INTRODUCTION or they, too, will quickly become ineffective because of the development of resistance. Thus a minimum of three to four new drugs are needed immediately to avert the escalation of drug-resistant TB.
In their retrospective review of how the New York City epidemic was brought under control, Frieden and colleagues (1995) credit more effective case finding and treatment and DOTS is an internationally recommended strategy for TB control. int/tb/dots/en/. The Stop TB Partnership, established in 2000, consists of almost 1,000 organizations from around the world. The primary goal of this alliance is to eliminate TB as a public health problem. org/. 46 THREAT OF DRUG-RESISTANT TUBERCULOSIS effective institutional transmission control.
Further underreporting may result from the fact that because MDR TB is underestimated in Africa, tools for its proper diagnosis in the region are not widely available. Even in settings where a national reference laboratory is in place to conduct drug resistance surveys, it is considered unethical to diagnose patients if second-line drugs capable of treating MDR TB are not available, which is the case in most countries where Ben Amor’s project, the Millennium Villages Project, has sites. An Example: KwaZulu-Natal Province in Rural South Africa Gerald Friedland of the Tugela Ferry Care and Research Collaboration provided a perspective on the MDR TB epidemic based on his experience in KwaZulu-Natal Province in rural South Africa, specifically Tugela Ferry.